Clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination.
Identifieur interne : 001862 ( Main/Exploration ); précédent : 001861; suivant : 001863Clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination.
Auteurs : Jun-Ichi Takanashi [Japon] ; Takashi Shiihara [Japon] ; Takeshi Hasegawa [Japon] ; Masaru Takayanagi [Japon] ; Munetsugu Hara [Japon] ; Akihisa Okumura [Japon] ; Masashi Mizuguchi [Japon]Source :
- Journal of the neurological sciences [ 1878-5883 ] ; 2015.
Descripteurs français
- KwdFr :
- Corps calleux (anatomopathologie), Encéphalite (anatomopathologie), Encéphalite (immunologie), Encéphalite (physiopathologie), Encéphalite (étiologie), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Hyponatrémie (sang), Hyponatrémie (étiologie), Imagerie par résonance magnétique, Mâle, Nourrisson, Protéines virales (immunologie), Vaccin antiourlien (effets indésirables), Électroencéphalographie.
- MESH :
- anatomopathologie : Corps calleux, Encéphalite.
- effets indésirables : Vaccin antiourlien.
- immunologie : Encéphalite, Protéines virales.
- physiopathologie : Encéphalite.
- sang : Hyponatrémie.
- étiologie : Encéphalite, Hyponatrémie.
- Enfant, Enfant d'âge préscolaire, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Nourrisson, Électroencéphalographie.
English descriptors
- KwdEn :
- Child, Child, Preschool, Corpus Callosum (pathology), Electroencephalography, Encephalitis (etiology), Encephalitis (immunology), Encephalitis (pathology), Encephalitis (physiopathology), Female, Humans, Hyponatremia (blood), Hyponatremia (etiology), Infant, Magnetic Resonance Imaging, Male, Mumps Vaccine (adverse effects), Viral Proteins (immunology).
- MESH :
- chemical , adverse effects : Mumps Vaccine.
- blood : Hyponatremia.
- etiology : Encephalitis, Hyponatremia.
- immunology : Encephalitis, Viral Proteins.
- pathology : Corpus Callosum, Encephalitis.
- physiopathology : Encephalitis.
- Child, Child, Preschool, Electroencephalography, Female, Humans, Infant, Magnetic Resonance Imaging, Male.
Abstract
We retrospectively collected three patients with clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination, and reviewed five patients, including two patients previously reported. The five patients (all males, aged 1 to 9) presented with fever, vomiting, or headache as the initial symptoms (day 0), suggesting meningitis, at 13 to 21 days after mumps vaccination. Consciousness disturbance, delirious behavior, seizures, or dysarthria was observed on days 1 to 3, which had completely resolved before day 11. Hyponatremia was observed in all patients. A cerebrospinal fluid study showed pleocytosis, and confirmed the vaccine strain genome. MRI revealed reduced diffusion in the splenium of the corpus callosum on days 2 to 4, which had completely disappeared on the follow-up studies performed on days 7-15. EEG showed high voltage slow wave in three patients, which later normalized. These findings led to a diagnosis of MERS after mumps vaccination. MERS after mumps vaccination may be more common than previously considered. MERS is suspected when a male patient after mumps vaccination presents with neurological symptoms with hyponatremia, following symptoms of aseptic meningitis, and MRI would be performed to examine the splenium of the corpus callosum.
DOI: 10.1016/j.jns.2014.12.019
PubMed: 25542078
Affiliations:
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Electronic address: jtaka44@hotmail.co.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo</wicri:regionArea><wicri:noRegion>Yachiyo</wicri:noRegion></affiliation></author><author><name sortKey="Shiihara, Takashi" sort="Shiihara, Takashi" uniqKey="Shiihara T" first="Takashi" last="Shiihara">Takashi Shiihara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Gunma Children's Medical Center, Shibukawa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Gunma Children's Medical Center, Shibukawa</wicri:regionArea><wicri:noRegion>Shibukawa</wicri:noRegion></affiliation></author><author><name sortKey="Hasegawa, Takeshi" sort="Hasegawa, Takeshi" uniqKey="Hasegawa T" first="Takeshi" last="Hasegawa">Takeshi Hasegawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Soka Municipal Hospital, Soka, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Soka Municipal Hospital, Soka</wicri:regionArea><wicri:noRegion>Soka</wicri:noRegion></affiliation></author><author><name sortKey="Takayanagi, Masaru" sort="Takayanagi, Masaru" uniqKey="Takayanagi M" first="Masaru" last="Takayanagi">Masaru Takayanagi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pediatrics, Sendai City Hospital, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pediatrics, Sendai City Hospital, Sendai</wicri:regionArea><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Hara, Munetsugu" sort="Hara, Munetsugu" uniqKey="Hara M" first="Munetsugu" last="Hara">Munetsugu Hara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics & Child Health, Kurume University School of Medicine, Kurume, Japan.</nlm:affiliation><country 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(physiopathology)</term><term>Female</term><term>Humans</term><term>Hyponatremia (blood)</term><term>Hyponatremia (etiology)</term><term>Infant</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mumps Vaccine (adverse effects)</term><term>Viral Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Corps calleux (anatomopathologie)</term><term>Encéphalite (anatomopathologie)</term><term>Encéphalite (immunologie)</term><term>Encéphalite (physiopathologie)</term><term>Encéphalite (étiologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Hyponatrémie (sang)</term><term>Hyponatrémie (étiologie)</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Nourrisson</term><term>Protéines virales (immunologie)</term><term>Vaccin antiourlien (effets indésirables)</term><term>Électroencéphalographie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Mumps Vaccine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Corps calleux</term><term>Encéphalite</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hyponatremia</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccin antiourlien</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Encephalitis</term><term>Hyponatremia</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Encéphalite</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Encephalitis</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Callosum</term><term>Encephalitis</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Encéphalite</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Encephalitis</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Hyponatrémie</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Encéphalite</term><term>Hyponatrémie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Infant</term><term>Magnetic Resonance Imaging</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Nourrisson</term><term>Électroencéphalographie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We retrospectively collected three patients with clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination, and reviewed five patients, including two patients previously reported. The five patients (all males, aged 1 to 9) presented with fever, vomiting, or headache as the initial symptoms (day 0), suggesting meningitis, at 13 to 21 days after mumps vaccination. Consciousness disturbance, delirious behavior, seizures, or dysarthria was observed on days 1 to 3, which had completely resolved before day 11. Hyponatremia was observed in all patients. A cerebrospinal fluid study showed pleocytosis, and confirmed the vaccine strain genome. MRI revealed reduced diffusion in the splenium of the corpus callosum on days 2 to 4, which had completely disappeared on the follow-up studies performed on days 7-15. EEG showed high voltage slow wave in three patients, which later normalized. These findings led to a diagnosis of MERS after mumps vaccination. MERS after mumps vaccination may be more common than previously considered. MERS is suspected when a male patient after mumps vaccination presents with neurological symptoms with hyponatremia, following symptoms of aseptic meningitis, and MRI would be performed to examine the splenium of the corpus callosum.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><noRegion><name sortKey="Takanashi, Jun Ichi" sort="Takanashi, Jun Ichi" uniqKey="Takanashi J" first="Jun-Ichi" last="Takanashi">Jun-Ichi Takanashi</name></noRegion><name sortKey="Hara, Munetsugu" sort="Hara, Munetsugu" uniqKey="Hara M" first="Munetsugu" last="Hara">Munetsugu Hara</name><name sortKey="Hasegawa, Takeshi" sort="Hasegawa, Takeshi" uniqKey="Hasegawa T" first="Takeshi" last="Hasegawa">Takeshi Hasegawa</name><name sortKey="Mizuguchi, Masashi" sort="Mizuguchi, Masashi" uniqKey="Mizuguchi M" first="Masashi" last="Mizuguchi">Masashi Mizuguchi</name><name sortKey="Okumura, Akihisa" sort="Okumura, Akihisa" uniqKey="Okumura A" first="Akihisa" last="Okumura">Akihisa Okumura</name><name sortKey="Shiihara, Takashi" sort="Shiihara, Takashi" uniqKey="Shiihara T" first="Takashi" last="Shiihara">Takashi Shiihara</name><name sortKey="Takayanagi, Masaru" sort="Takayanagi, Masaru" uniqKey="Takayanagi M" first="Masaru" last="Takayanagi">Masaru Takayanagi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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